Katerina Siniakova vs Amanda Anisimova Prediction & Betting Pick | Australian Open (Women) January 21, 2026

📅 Date: Wednesday, January 21, 2026
🕖 Time: 9:30 PM EST
🏟️ Venue: Margaret Court Arena - Melbourne, Australia

Anisimova’s power profile makes this one feel tidy. Siniakova will try to mix things up — slices, off‑tempo balls, angles — but Amanda’s strength is taking the ball early and refusing to let rallies drift into awkward territory. When she steps in, she forces short points and keeps opponents on the back foot.

Siniakova’s variety can frustrate hitters who let her dictate, but this matchup isn’t about patience. Anisimova doesn’t give opponents time to set traps; she hits through them. That directness neutralizes the Czech’s biggest weapon: disruption. Expect the American to control the rhythm from the baseline.

Look at recent form and context. Siniakova’s opening match was tidy — a quick straight‑sets win — but history in Melbourne shows she rarely goes deep in singles here. Her doubles résumé is impressive, yet singles at the Australian Open has never been her strong suit. That matters against a top‑level ball‑striker.

Anisimova’s results over the past year aren’t flukes. Two Grand Slam finals, a China Open title, and big wins at the WTA Finals show she can sustain elite level across weeks. That experience translates into cleaner decision‑making in early rounds: fewer lapses, fewer extended games, and a higher chance of a straight‑sets finish.

From a matchup standpoint, the weight of Anisimova’s groundstrokes forces Siniakova into defensive positions. When rallies speed up, Siniakova’s margin for error shrinks. She can manufacture points, but against heavy, early ball‑striking, those manufactured points are rarer and shorter.

The under 20.5 is logical here. If Anisimova executes her plan — step in, take the ball early, finish points — the match won’t stretch into long, grinding games. Short points plus a straight‑sets result equals a low total of games. The numbers line up with the style contrast.

Siniakova’s serve and touch help her against mid‑level opponents, but Anisimova’s return quality and depth change the equation. Break opportunities will come for Amanda, and once she gets a lead in each set, she’s likely to close without drama. That’s the scenario where the -4.5 holds up.

Mental edge matters too. Anisimova has been in high‑pressure matches recently and shown she can close them. Siniakova, while crafty, hasn’t demonstrated the same singles consistency at majors. That experience gap often shows in the second set when the favorite tightens up and the underdog runs out of answers.

I’m backing the American across three correlated angles: straight sets, a comfortable spread, and a low total. They’re different ways of expressing the same read — Anisimova’s power and tempo control should make this brief and decisive.

📌 Official Picks
Under 20.5 Games (-110)
Amanda Anisimova 2-0 (-120)
Amanda Anisimova -4.5 (-120)

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