Tennessee Titans at Denver Broncos Prediction & Betting Pick | NFL Week 1

📅 Date: Sunday, September 7, 2025
🕖 Time: 4:00 PM EST
🏟️ Venue: Mile High Stadium, Denver, Colorado

Game Preview

The Denver Broncos kick off their 2025 campaign at home in Mile High with expectations sky-high under Sean Payton. Denver’s roster is built to contend in the AFC, and with a challenging second half of the schedule looming, they’ll need to stack wins early. Facing last year’s worst team, the Tennessee Titans, is a prime opportunity to make a statement.

Rookie quarterback Cam Ward, the No. 1 overall pick, leads Tennessee into his NFL debut. While his talent is undeniable, history isn’t on his side — rookie QBs often struggle in their first road start, especially against elite defenses. Unfortunately for Ward, he draws one of the NFL’s most dangerous pass-rush units right out of the gate. Denver’s defense led the league in pressure rate last season, anchored by the reigning Defensive Player of the Year and an improving front seven that thrives at home in altitude.

Why Denver Has the Edge

Defensive Pressure: Ward will be under fire all afternoon. Expect turnovers to set up short fields for the Broncos’ offense.

Sean Payton Factor: Year 2 in Payton’s system should see growth from rookie QB Bo Nix. Even if the offense starts slow, Payton’s schemes typically hit stride as the game wears on.

Balanced Attack: With upgrades in the run game and weapons like Evan Engram and Troy Franklin, Denver should be able to complement their defense with steady scoring drives.

Home Field Advantage: Denver hasn’t lost a season opener at home since 2016, and the altitude is always a factor against a young QB.

What to Expect

Tennessee will scrap to stay competitive, but relying on field goals won’t be enough in Mile High. Denver’s defense should frustrate Cam Ward into mistakes, while Nix and the offense gradually find rhythm after a shaky start. Look for Denver to establish control by the second quarter, lean on their defense, and close the game out comfortably.

This game has all the makings of a “statement win” for a Broncos team entering what Payton calls their Super Bowl window.

📌 Official Pick

Denver Broncos -8.5 (-116)

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