Philadelphia 76ers at Boston Celtics Prediction & Betting Pick | NBA 2025-26 October 22, 2025

📅 Date: Wednesday, October 22, 2025
🕖 Time: 7:30 PM EST
🏟️ Venue: TD Garden - Boston, MA

With Jayson Tatum out, this becomes Jaylen Brown’s show — and he’s built for it. This matchup could easily push him closer to 40 minutes against Philly and Embiid. When Boston’s missing their main star, Brown slides right into that alpha role. He’s capable of 25-30 points without breaking a sweat, and tonight’s setup points straight toward that range.

Without Tatum, Brown is going to have the ball in his hands constantly. He’s their primary scorer and top shot-maker now, and Philly’s defense doesn’t have the same bite on the perimeter. Expect Boston to lean into pace — something Brown’s been pushing for the last couple years. That’s where he thrives: in transition, attacking open lanes, and creating chaos.

We’ve seen flashes of what he can do when he’s the main guy. In the last 10 games without Tatum, Brown has averaged 24.2 points, 6.9 rebounds, and 6.7 assists, and that came with fewer touches than he’ll likely see tonight. The volume is there, the role is there, and the motivation definitely is. He’s already shown he can score efficiently even when defenses load up on him.

What makes this interesting is how Boston will adjust stylistically. Brown becomes the focal point of both isolation and transition plays. At home, in a prime-time spot, without Tatum — this is the kind of game where Brown usually reminds people he’s an All-NBA scorer in his own right. The opportunity is massive, and everything aligns for a strong performance.

📌 Official Pick

Jaylen Brown (Boston Celtics) Over 24.5 Points -102

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