Jacksonville Jaguars at Denver Broncos Prediction & Betting Pick | NFL Week 16 December 21, 2025
đź“… Date: Sunday, December 21, 2025
đź•– Time: 4:05 PM EST
🏟️ Venue: Empower Field - Denver, CO
Jakobi Meyers has quietly become Trevor Lawrence’s most reliable option since the trade from Las Vegas. He’s hit 63, 68 and 97 yards in his last three games and has seen double‑digit targets in each of the last two — that kind of volume is the backbone of this play. When a receiver is getting that many looks, clearing 54.5 yards is more a function of opportunity than variance.
Jacksonville isn’t coasting. They’ve won five straight to sit 10‑4, and a win in Denver would put them in a great spot to clinch a playoff berth. That urgency matters: when a team needs a result, the offense leans on its trusted pass catchers. Expect Lawrence to look Meyers’ way early and often if the Jaguars are pressing for a decisive road victory.
Meyers has settled into the offense quickly. The targets are consistent, his route tree is varied, and he’s shown the ability to turn short catches into chunk plays. Those intermediate gains add up fast — you don’t need a 100‑yard game to clear 54.5 when you’re catching a steady stream of passes.
Game script favors volume. Jacksonville will likely try to keep pace and avoid a shootout in Denver’s altitude by moving the chains through the air. If the Jaguars are playing to clinch, they’ll prioritize possessions and trusted matchups; Meyers is the obvious beneficiary of that approach.
Matchup specifics aren’t the headline here — this is about usage. Meyers’ recent target counts and yardage profile give him a high floor. Even if the Broncos mix coverages, the sheer number of looks he’s getting makes the reception and yardage totals predictable and bankable.
There’s always risk — a fluke injury, a surprise defensive scheme, or a game that turns into a run‑heavy slog — but the market line reflects those possibilities. At -110 and with the usage trends we’ve seen, the edge is on the over. I’m sizing this one up at 3 units because the volume and context line up in Meyers’ favor.
đź“Ś Official Picks
Jakobi Meyers (Jacksonville Jaguars) Over 56.5 Receiving Yards -112
